Download Roncoleukin^®: Guidelines for Veterinarians

 

RONCOLEUKIN^®

International unlicensed name:

Recombinant human INTERLEUKIN-2

 

DRUG FORMULATION

Roncoleukin^® - recombinant interleukin-2 (rIL-2) - is a structural and functional analogue of endogenous human interleukin-2. Roncoleukin^® is isolated from cells of non-pathogenic brewer’s yeast Saccharomyces cerevisiae containing gene of human interleukin-2 (IL-2).

 

COMPOSITION

·     recombinant interleukin-2 (rIL-2);

·     sodium dodecyl sulphate (SDS) – solubilizer;

·     D-mannit (stabilizer);

·     dithio treitol (reduction agent).

·      

PHARMACOLOGICAL GROUP

Pharmacological group – 6.5. Immune modulators.

 

BIOLOGICAL PROPERTIES

·     Roncoleukin^® restores synthesis of endogenous interleukin-2 by activated CD4+ and CD8+ cells. Compensates deficit of endogenous of interleukin-2.

·     Roncoleukin^® acts on cells-targets: NK-cells, T-helpers, cytotoxic T-lymphocytes, B-lymphocytes, monocytes, being for them factor of activation, proliferation and differentiation.

·     Roncoleukin^® regulates Th1/Th2 balance.

·     Roncoleukin^® abolishes immune tolerance, preserves activated T-cells from untimely death.

·     Roncoleukin^® performs regulation and cooperation of mechanisms of inherent and acquired immunity.

·     Roncoleukin^® stimulates realization of antigen-dependent and independent immune response, acts on cellular and humoral immunity.

Roncoleukin^® possesses anti-neoplastic and anti-infectious activity, activates processes of tissue reparation and regeneration, promotes adequate interaction of immune, endocrine and nervous systems.

 

PHARMACOKYNETICS

At intravenous infusion it has been noticed quick growth of IL-2 concentration in plasma, its half-life period in serum is 5-7 minutes. In subcutaneous infusion the half-life period is increased three times. Elimination is performed through kidneys by proteolysis until separate amino acids.

 

POSSIBILITIES OF RONCOLEUKIN^® IN THE VETERINARY SCIENCE

It is recommended to use Roncoleukin^® in the veterinary practice for curing mammals (pets, horses, cattle, small cattle, swine, rodents and others), birds, reptilians and fish.

Roncoleukin^® is used in the form of mono-therapy or as a component of complex therapy for animals of various diseases and conditions:

-      pyoinflammatory diseases;

-      infection diseases:

-      skin diseases:

-      diseases of eyes:

-      diseases of mouth cavity:

-      respiratory diseases:

-            diseases of the digestive tract:

-      hereditary diseases:

-      stress;

-      surgery:

-      oncology:

-      adjuvant vaccine;

-      violation of  mineral metabolism;

-      parasitology:

-      geriatrics.

 

 Download Roncoleukin^®: Guidelines for Veterinarians